Genius of the Rules-Style System - Chapter 735

c726 Nobel level results

Through the verification of the “Law of Causality”, Zhao Yi has determined that according to his analysis, the detection mechanism in the immune response process indeed uses protein sorting as the ‘detection code’.

He announced the inferred results in public, but did not confirm that this was the case.

In many experimental studies, imagination and judgment are very important, and it is not necessary to verify the judgment, because many judgments cannot be verified.

That’s it for now.

It is impossible to conduct experimental verification before further results are confirmed.

So Zhao Yi directly arranged the next work: doing protein elimination research.

Because there are as many as eleven types of proteins that may be related to immune rejection, and not all of them may be directly related to one protein.

This is a definite conclusion.

They must filter out those that are relevant and eliminate those that are not.

Protein exclusion research is more complicated. We can understand 11 related proteins in this way. They are all proteins distributed on human cell membranes.

Some proteins are involved in the detection of immune responses, and some proteins have other functions.

So if you want to detect which of the proteins are directly related to the immune response, you must perform extraction experiments one by one, and then inject the extracted single protein into the target body.

The target, and the target from which the protein is extracted must be from the same source.

In fact, the best choice is the human body, not certain organs, parts or blood. But now that they have not applied to allow volunteers to participate in the experiment, they can only conduct auxiliary research in other ways.

Then the process becomes more complicated.

For each protein, many experiments must be conducted. After obtaining the data, detailed analysis must be conducted and many comparisons must be made to determine the relevance of the immune response.

It is also very difficult to analyze the correlation, because there is no definite way to do it, so you can only take out the data and analyze it continuously.

The laboratory is still confident in this work.

Because Zhao Yi is here.

Zhao Yi is the top mathematician. He is very sensitive to numbers and can always see the key points.

Therefore, people in the laboratory are very confident, and the entire laboratory has devoted their energy to the study of protein exclusion, including several researchers, a dozen associate researchers, and even a dozen assistant researchers.

The laboratory is busy, with experiments everywhere and reports everywhere.

Zhao Yi sat in the central office and kept looking at the experimental designs and results that were sent to him. This busy state lasted for about a week before he finally got the positive results.

The laboratory held a summary meeting.

Zhao Yi announced, “Through a series of experiments and analyses, we determined that seven proteins are directly related to immune detection, and the other four proteins are not related.”

He passed a report to everyone, detailing the comparison of the data in the experiment.

Without this clear report, anyone would have a headache when faced with a lot of experiments and data. But by comparing the data in the report, they can clearly see that the results are divided into two data situations. The data of the seven proteins are similar, one situation, and the data of the other four proteins are another situation.

This clearly illustrates that the seven proteins listed are directly related to immunoassays.

“Based on the conclusions drawn from the last experiment, we can infer that the key to immune detection lies in the arrangement of these seven proteins.”

Zhao Yi went to the whiteboard and drew a picture. The human cell membrane was marked on the picture. There was an antenna growing on the cell membrane. The antenna was composed of a long series of seven circles. He explained, “This is the key to immune detection.”

“People with different blood types have different blood group antigens on red blood cells, and blood group antigens refer to proteins on the surface of cell membranes.”

“We all know that the difference in blood group antigens refers to the difference in protein expression. For example, between blood type A and type B, the molecular bonds at the ends of the antigenic proteins are slightly different.”

“People of the same blood type have the same antigenic proteins. When the antigenic proteins are consistent, the immune detection can pass the first stage. This is the first step.”

“Even people with the same blood type will have certain immune rejection reactions. Why is this? Because of immune testing, there is a second step, which is also the most critical step: protein sequence testing.”

“The seven proteins we found are all directly related to immunoassays, and different people will have different protein ranking combinations.”

“Detecting the contacts of cells will result in corresponding sorting detection, and detecting different protein sortings will trigger an immune response.”

After Zhao Yi finished speaking, he pondered for a moment, giving everyone time to digest the information, and then continued, “There may be 5,040 possible rankings of seven types of proteins.”

“In other words, the same blood type will have 5,040 different immune characteristics.”

“This is a conclusion we have drawn through summary and analysis of experimental data. It is just a possibility, but we can use it to design verification experiments.”

“For example, finding people who share the same immune profile.”

“Hula——”

After Zhao Yi said his last words, it immediately aroused heated discussion in the conference room.

The medical community recognizes that no one has the same immune characteristics. In other words, everyone’s body will have an immune rejection reaction against other people’s cells.

This conclusion is already recognized.

But thinking about it carefully, it seems that no institution has conducted a sufficient number of experiments to verify it.

This is also normal.

Generally, contact with other people’s cells is accomplished through blood transfusions and organ transplants. The immune rejection reaction of blood transfusions of the same blood type is not significant. Even if there is no immune rejection reaction, it will not be known without detailed testing.

The number of organ transplants is even smaller. Even if the subsequent immune rejection is very small, most of it will be attributed to the effect of the drug or the patient’s ability to recover.

In addition, according to the data mentioned by Zhao Yi, the chance of the same immune characteristic appearing is also very small.

The same blood type has 5,040 immune characteristics.

Detailed screening verification must be a very huge task.

After the conference room became quieter, Zhang Wei asked, “How to conduct such a large screening experiment? We must cooperate with the hospital to obtain enough blood samples and enough data.”

Li Ming shook his head and said, “Just one hospital is not enough. Because we cannot verify this conclusion only through blood. We must also cooperate with other medical and experimental institutions.”

Others chimed in with their opinions.

It is easy to verify whether there is immune rejection, but it is very difficult to obtain enough sample data to conduct targeted experiments.

This is a simple yet huge job.

There are 5,040 immune characteristics of the same blood type. If you want to find people with the same immune characteristics, you will have to conduct at least a thousand experiments. If you are not lucky, you will even have to conduct tens of thousands of experiments. The samples and materials required are, And the workload of the experiment is absolutely huge.

Zhao Yi nodded and said, “I will tell the institute to let other experimental staff to cooperate with the research. In addition, I will apply for research and development funds and strive to get more funds.”

“This kind of research is international in nature and cannot all be funded by the laboratory.”

“Also, you can publish the results first——”

Zhao Yi’s last words were a bit sudden, but his meaning was very clear. After the results are published, other institutions may do the verification.

This kind of verification experiment can be done by anyone. With other institutions helping to verify it, they don’t need to waste time and effort to verify it.

That makes no sense at all.

After the meeting ended, everyone in the laboratory was talking about the relevant conclusions. Everyone knew what the correct conclusion meant –

This will be a Nobel Prize-level achievement in medicine.

——

Zhao Yi is very sure of the experimental results, so he has the confidence to publish the results directly. As for verification, he can proceed slowly.

It would be a great situation if other organizations could help verify it.

At the same time, elucidating the mechanism of human immune detection is to improve the mechanism of the human immune process and is also very important for future treatment and drug development.

This research can be invested in clinical applications and drug development, and there are many directions that can be considered.

After confirming the publication of the research paper, Zhao Yi went to the genetic laboratory and found the main researcher Zhang Ning. Zhang Ning had been working in the genetic laboratory, and the research he applied for personally had made considerable progress.

Just because research has progressed, Zhang Ning’s work has become even busier.

After Zhao Yi found Zhang Ning, he directly explained the purpose of his visit, “I hope your laboratory can conduct analysis at the genetic level based on our conclusions to enrich the relationship between the HLA gene system and the outer layer of cells proteins.”

He then talked about the experimental conclusions in detail.

Zhang Ning has been working in the genetic laboratory and has not participated in the research in Zhao Yi’s laboratory. She knew that the laboratory was very busy, but she never expected to draw such an important conclusion, “Are you sure? Zhao Yi Academician? Has this conclusion been verified?”

“Not yet, but I’m sure.” Zhao Yi talked about some data and said that he was ready to publish the results.

Zhang Ning nodded and said seriously, “If your research is correct, it is absolutely amazing. It is very important for enriching the relationship between genes and cells.”

“However, this is no longer about making me work, but giving me the results.”

She smiled bitterly as she spoke.

Genetic experts are engaged in genetic research, and naturally they hope to make breakthroughs in genetic research.

If Zhao Yi’s conclusion is correct, then we can directly connect the HLA gene system and cell membrane proteins, and conduct a detailed analysis of immune detection from the genetic and molecular levels. Isn’t it equivalent to putting the results in front of us?

Zhao Yi said nonchalantly, “As long as we publish the results, there will definitely be corresponding laboratories to do research.” What he means is that instead of giving the results to others, it is better to give them to one’s own people, and their research conclusions will also be given to others. Research support at the genetic level is needed.

The HLA gene system mentioned by the two people is the main histocompatibility complex in humans. It is the most polymorphic genetic system in humans known so far. It has been determined to be located in the 6p21.31 region of the short arm of chromosome 6. .

The HLA system, composed of a series of closely linked gene positions, constitutes the “identity card” of human biology.

The medical community believes that each individual’s immune active cells use HLA as a mark to identify “self” and “non-self”, thereby eliminating “non-self” through immune responses and maintaining the integrity of the individual.

In other words, the HLA gene system controls the genes that determine the sequence of immune detection proteins.

If it can be supported by the conclusions of HLA gene system research, it can corroborate the results of immune detection protein sequences. Even if no one with the same immune characteristics has been found yet, it will be highly convincing.

Zhao Yi talked about research issues with Zhang Ning and was also concerned about Zhang Ning’s personal project. However, he soon found that he could not say anything about Zhang Ning’s project because Zhang Ning was doing gene-related research and improving human genes. The library is only one aspect, which is relatively understandable, while the other aspects are more complicated.

Later, Zhao Yi simply stopped talking.

After walking out of the genetic laboratory, Zhao Yi thought back and realized that he still underestimated science. He originally thought that he was already ‘all-powerful’ and would definitely know something about fields where he had never done any research.

Now he discovered that the scope of science is infinitely broad. Medical research alone contains a huge amount of knowledge, including neurology, genetics, immune research, etc. There are many theoretical studies. When it comes to a completely new field, he still works with him. It was the same at first, it seemed like I understood something, but in fact, when it came to advanced content, I still didn’t understand anything.

“Industry specializing in surgery!”

“It’s impossible for me to take care of science myself -” Zhao Yi laughed at himself, and suddenly felt that the decision to establish a genetic laboratory was extremely wise.

He returned home leisurely.

In the evening, Yixing was conducting a company video conference, and he heard some interesting news.

Professor Bai Jianwu from the Microbiology Technology Laboratory applied to participate in microbiological research at the moon base and passed the initial physical test.

“Professor Bai?”

“It’s really amazing!” Zhao Yi said with some sigh.

Although it is said that the age limit for working at the lunar base is fifty years old, in fact, it is not easy for people over 45 years old to pass the physical examination.

First of all, if you don’t have any basic diseases and pass the dizziness test, you can get rid of more than 60% of people.

Few people who have done research for a long time are in very good health, and some basic conditions are not very common. For example, high blood pressure is very common.

Young people are relatively better off. Even if they are obese and have slightly higher blood pressure, they can be lowered by losing weight.

After the age of forty-five, it is very difficult to cure high blood pressure. If it is more serious, heart problems will occur.

In addition, the dizziness test is definitely a critical blow to older people.

It can be said that Bai Jianwu passed the physical test, which is remarkable. He has rich research and development experience and is indeed suitable for working on the moon.

Zhao Yi raised his head while thinking, looked at the full moon outside the window, and couldn’t help but think of Li Renzhe.

Li Renzhe is up there now. If you count the time, he will be back soon, right?