Great Power Technology - Chapter 634

c624 Phase zero experimental results

On the other side, after all obstacles have been cleared, the zero-stage research and development of immune reconstitution therapy has finally come to an end.

——

Yes, it’s not the beginning, but the end.

In fact, after receiving the technical documents provided by Ye Zhou, a research team composed of top domestic clinical experts has been mobilized, and their task is also very simple, that is, in accordance with the technical manual 100%, in the laboratory Completed the first case of immune reconstitution therapy.

Now, they have completed all mouse experiments and are discussing the actual efficacy and human safety results before the latest output report.

“Has the preclinical model of B-NDG mice been released? What are the results?”

The question was asked by a white-haired old man sitting in the middle, named Xuancheng. He is a veteran in the field of immune reconstitution therapy in China and has made great contributions to PBMC therapy.

“Basically, it has come out. Judging from the current results, the survival rate of this batch of mice has reached 100%, but the survival cycle fluctuates. Within a period of time after the experiment, more than 20% of the mice appeared Significant weight loss.”

“At the same time, we also observed that a small number of experimental subjects became manic, anxious, and even self-biting.”

“Controlled experiments have been conducted many times, including adjustments to the dose and therapy of PBMC, but strangely, this problem still exists.”

The person who answered was Lin Qingshu, the leader of the zero-phase working group. His face was full of doubts, and he seemed completely confused about the result.

In fact, if you look at it from his perspective, this problem is as evil as a ghost.

All the variables that can be adjusted and controlled have been adjusted, and all man-made or non-man-made disturbances have been eliminated. They even changed several experimental chambers, but the mice that should be sick are still sick.

——

In other words, it cannot be called an illness, because the mice did not show obvious pathological symptoms, and their physical signs were all normal. If the requirements of other non-core experiments were followed, this could even be ignored as a non-critical factor.

After all, there are many reasons why mice go crazy. It may be because of temperature changes, it may be because the air is too dry, or it may even be because of an accidental step on static electricity…

However, in a project like this, he could not ignore any minor anomalies, because at this stage they were not exploring, but just copying.

The first basic theorem he can determine is: Rather than questioning whether technical documents will be wrong, it is better to re-examine the execution process.

Therefore, based on this judgment, they even changed the fresh air system in the laboratory, but they still did not solve the problem of treated mice going crazy from time to time.

“Could it be that a high proportion of human immune cells causes the GVHD problem?”

Xuancheng asked with a frown.

The so-called GVHD is commonly known as graft-versus-host disease, which may occur in any immune reconstitution therapy involving PBMC.

“No, we have tried to adjust it many times and have eliminated most of the variables. We are sure that it is not caused by GVHD.”

“What about the operating procedures? Are there any non-standard actions caused by human factors?”

“No, we just have to play back the video frame by frame.”

Lin Qingshu sighed and spread his hands helplessly.

Hearing this, everyone in the conference room fell silent. They all knew how important the zero-stage experiment of this project was.

Not only because the laboratory results will be urgently applied to a group of patients with severe immune diseases to save their remaining lives.

More importantly, this result will verify an important question:

That is, whether the immune reconstruction technology has broken through the current upper limit of human technology in the entire process.

If you can’t even replicate it in the laboratory, there’s no need to talk about large-scale rollout.

The entire subsequent project strategy will be affected. The originally planned “results”-oriented strategy will gradually be transformed into a “construction”-oriented strategy, and the resource investment plan will also need to be changed.

“Could it be an allergic reaction?”

After a few seconds of silence, Xuancheng continued to ask.

“Allergic reaction?”

Lin Qingshu was stunned for a moment, unable to realize what the other party meant.

In fact, allergic reactions are not particularly rare in experiments, but the problem is that if allergies occur, it means there is a problem with the equipment or medicine used. All mice in the same batch should be allergic, so why are there only a few? What if there is only one problem?

But having said that, the mice are now acting a bit like allergies.

He frowned and thought for a moment before replying:

“It seems that we haven’t checked IGE yet… In this case, I will ask the laboratory to check IGE first. If the value continues to be high, then consider allergic reactions.”

“But the problem is, we have never had this situation before…”

“Don’t worry about whether you showed up or not.”

Xuancheng interrupted him and continued:

“Since you have done complete experiments and eliminated all other variables, allergies are the most likely cause of the problem.”

“You don’t have to be too unsure of yourself. This technology is indeed very advanced, but it is not beyond your capabilities.”

“There is no need to suspect that there is something wrong with you if there is an abnormal result – go check IGE first!”

“clear!”

Lin Qingshu went out with the report, while Xuancheng continued to stay where he was to look at the overall experimental results.

As Lin Qingshu reported before, judging from the final data results, the results of the entire zero-stage experiment are very good. If it were not for the intermittent mania in mice, we could even directly conclude the application and start applying for human trials.

The entire project is very tight, and if it is delayed now, it will affect the entire cycle.

what is the reason behind the scene?

Lin Qingshu is right. Allergic reactions should not only appear in some mice, because the variables are all the same. It is impossible for one batch of mice to be allergic to a certain allergen and another batch not to be allergic, right?

The probability is there, but it’s really low.

He was immersed in his own thoughts, and time passed quickly. In less than half an hour, the door of the conference room was pushed open again.

“Teacher Xuan, IGE is really elevated, it seems like it is an allergy!”

Xuancheng perked up and continued to ask:

“Can you locate the allergen?”

“We can’t locate them at the moment, but we can test them one by one… It shouldn’t take long.”

“Besides, I have a hunch that the problem this time is likely to occur on the device!”

“Equipment? What equipment?”

Xuancheng asked doubtfully.

“Needle! Or it’s not a needle, it’s SUT!”